MESENCHYMAL STEM CELL (MSC) SECRETOME
What is stem cell secretome therapy?
It is an experimental therapy that we use as part of individualized treatment for patients who may have a clear benefit from the therapy. In stem cell secretome therapy, stem cells are obtained from the patient’s own adipose tissue (autologous stem cells, adipose stem cells, adipogenic stem cells, ADSCs).
This initial small number of stem cells is grown and expanded (multiplied) in the pharmaceutical clean-room laboratory. This allows to obtain significantly more stem cells than e.g. in BMC without propagation.
The goal of this process is to increase the number of stem cells, induce the production of the potentially regenerative and anti-inflammatory substances that stem cells release to the outside, concentrate them and use them for treatment. Instead of implanting or injecting stem cells into the patient, only the produced cellular components, i.e. the secretome, are applied.
Compared to direct injection of stem cells, the risks of this method are relatively lower.
What are the Advantages of Treatment With Stem Cell Secretome Compared to Stem Cells?
In short, compared to BMC, pure mesenchymal stem cells are obtained and several doses can be obtained from one tissue collection, which makes it particularly suitable for the treatment of chronic diseases.
Moreover, the secretome is storable, fully quality controlled before use and is made from 90-98% pure MSC mesenchymal stem cells.
The use of stem cells is still limited in most countries. This has severely limited their use in medicine despite their presumed and in some cases clinically proven efficacy in treating many chronic or incurable diseases. Reasons for this include the fact that stem cells can lose their efficacy if they expand too much, altered cells can develop, and stem cells, at least those derived from blood (hematopoietic stem cells), are altered when frozen, which in turn alters their potential efficacy, including the composition of the substances they deliver to the outside world.
This may now be changing, with one of the latest breakthroughs in stem cell research: the science team has developed and implemented a process that extracts and concentrates the components of stem cells that are evidence-based to be therapeutically active – the stem cell secretome.
The secretome that we use from Offenbach provides safety in several respects.
No living cells are injected into the patient, i.e. no altered stem cells can be injected.
The secretome is made of mildly expanded (i.e. potentially less altered cells). Thus, the composition is the natural one, which is not altered by freezing.
After production, the secretome can be stored in this composition. Exosomes and other substances contained in the secretome remain stable. This allows to produce numerous doses with one withdrawal, which can then be used for more than 2 years.
Thus, treatment with secretome is the better option especially for chronic diseases.